Affiliation:
1. Department of Biology, Faculty of Science and Letters, Manisa Celal Bayar University, Muradiye, Manisa, Turkey
2. Department of Biology, The Institute of Natural and Applied Sciences, Manisa Celal Bayar University, Muradiye, Manisa, Turkey
Abstract
Abstract:
Cancer is a disease characterized by uncontrolled cell proliferation and the spread of cells to other
tissues and remains one of the worldwide problems waiting to be solved. There are various treatment strategies
for cancer, such as chemotherapy, surgery, radiotherapy, and immunotherapy, although it varies according to its
type and stage. Many chemotherapeutic agents have limited clinical use due to lack of efficacy, off-target toxicity,
metabolic instability, or poor pharmacokinetics. One possible solution to this high rate of clinical failure is
to design drug delivery systems that deliver drugs in a controlled and specific manner and are not toxic to normal
cells. Marine systems contain biodiversity, including components and materials that can be used in biomedical
applications and therapy. Biomaterials such as chitin, chitosan, alginate, carrageenan, fucoidan, hyaluronan,
agarose, and ulvan obtained from marine organisms have found use in DDSs today. These polysaccharides are
biocompatible, non-toxic, biodegradable, and cost-effective, making them ideal raw materials for increasingly
complex DDSs with a potentially regulated release. In this review, the contributions of polysaccharides from
the marine environment to the development of anticancer drugs in DDSs will be discussed.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
5 articles.
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