Author:
Coelho Camila H.,Tang Wai Kwan,Burkhardt Martin,Galson Jacob D.,Muratova Olga,Salinas Nichole D.,Silva Thiago Luiz Alves e,Reiter Karine,MacDonald Nicholas J.,Nguyen Vu,Herrera Raul,Shimp Richard,Narum David L.,Byrne-Steele Miranda,Pan Wenjing,Hou Xiaohong,Brown Brittany,Eisenhower Mary,Han Jian,Jenkins Bethany J.,Doritchamou Justin Yai Alamou,Smelkinson Margery G.,Vega-Rodriguez Joel,Trück Johannes,Taylor Justin J.,Sagara Issaka,Renn Jonathan P.,Tolia Niraj H.,Duffy Patrick E.
Abstract
ABSTRACTMalaria elimination requires tools that interrupt parasite transmission. Here, we characterized B cell receptor responses among Malian adults vaccinated against the first domain of the cysteine-rich 230kDa gamete surface protein Pfs2301–3 to neutralize sexual stage P. falciparum parasites and halt their further spread. We generated nine Pfs230 human monoclonal antibodies (mAbs). One mAb potently blocked transmission to mosquitoes in a complement-dependent manner and reacted strongly to gamete surface while eight mAbs showed only low or no blocking activity. This study provides a rational basis to improve malaria vaccines and develop therapeutic antibodies for malaria elimination.
Publisher
Cold Spring Harbor Laboratory
Cited by
3 articles.
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