A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite-Reference-Cited by-同舟云学术

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Published:2018-03-19 Issue:4 Volume:24 Page:408-416
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Kisalu Neville K,Idris Azza H,Weidle Connor,Flores-Garcia Yevel,Flynn Barbara J,Sack Brandon K^ORCID,Murphy Sean,Schön Arne,Freire Ernesto,Francica Joseph R,Miller Alex B,Gregory Jason,March Sandra,Liao Hua-Xin,Haynes Barton F,Wiehe Kevin,Trama Ashley M,Saunders Kevin O,Gladden Morgan A,Monroe Anthony,Bonsignori Mattia,Kanekiyo Masaru^ORCID,Wheatley Adam K,McDermott Adrian B,Farney S Katie,Chuang Gwo-Yu,Zhang Baoshan,Kc Natasha,Chakravarty Sumana,Kwong Peter D,Sinnis Photini,Bhatia Sangeeta N,Kappe Stefan H I,Sim B Kim Lee^ORCID,Hoffman Stephen L,Zavala Fidel,Pancera Marie,Seder Robert A

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.4512.pdf

Reference71 articles.

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3. Ancsin, J.B. & Kisilevsky, R. A binding site for highly sulfated heparan sulfate is identified in the N terminus of the circumsporozoite protein: significance for malarial sporozoite attachment to hepatocytes. J. Biol. Chem. 279, 21824–21832 (2004).

4. Rathore, D., Sacci, J.B., de la Vega, P. & McCutchan, T.F. Binding and invasion of liver cells by Plasmodium falciparum sporozoites. Essential involvement of the amino terminus of circumsporozoite protein. J. Biol. Chem. 277, 7092–7098 (2002).

5. Dame, J.B. et al. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225, 593–599 (1984).

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