Drug-Target Interaction prediction using Multi-Graph Regularized Deep Matrix Factorization

Abstract

AbstractDrug discovery is an important field in the pharmaceutical industry with one of its crucial chemogenomic process being drug-target interaction prediction. This interaction determination is expensive and laborious, which brings the need for alternative computational approaches which could help reduce the search space for biological experiments. This paper proposes a novel framework for drug-target interaction (DTI) prediction: Multi-Graph Regularized Deep Matrix Factorization (MGRDMF). The proposed method, motivated by the success of deep learning, finds a low-rank solution which is structured by the proximities of drugs and targets (drug similarities and target similarities) using deep matrix factorization. Deep matrix factorization is capable of learning deep representations of drugs and targets for interaction prediction. It is an established fact that drug and target similarities incorporation preserves the local geometries of the data in original space and learns the data manifold better. However, there is no literature on which the type of similarity matrix (apart from the standard biological chemical structure similarity for drugs and genomic sequence similarity for targets) could best help in DTI prediction. Therefore, we attempt to take into account various types of similarities between drugs/targets as multiple graph Laplacian regularization terms which take into account the neighborhood information between drugs/targets. This is the first work which has leveraged multiple similarity/neighborhood information into the deep learning framework for drug-target interaction prediction. The cross-validation results on four benchmark data sets validate the efficacy of the proposed algorithm by outperforming shallow state-of-the-art computational methods on the grounds of AUPR and AUC.