Author:
Artan Murat,Jeong Dae-Eun,Lee Dongyeop,Kim Young-Il,Son Heehwa G.,Husain Zahabiya,Kim Jinmahn,Altintas Ozlem,Kim Kyuhyung,Alcedo Joy,Lee Seung-Jae V.
Abstract
Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans’ life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs.
Funder
Ministry of Education, Science and Technology
National Research Foundation (NRF) of Korea
Ministry of Health and Welfare
NRF grant
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
33 articles.
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