Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

Author:

Li Hongjie,Janssens Jasper,De Waegeneer Maxime,Kolluru Sai Saroja,Davie Kristofer,Gardeux VincentORCID,Saelens Wouter,David Fabrice,Brbić Maria,Leskovec Jure,McLaughlin Colleen N.,Xie Qijing,Jones Robert C.,Brueckner Katja,Shim Jiwon,Tattikota Sudhir Gopal,Schnorrer FrankORCID,Rust Katja,Nystul Todd G.ORCID,Carvalho-Santos Zita,Ribeiro Carlos,Pal SoumitraORCID,Przytycka Teresa M.,Allen Aaron M.,Goodwin Stephen F.,Berry Cameron W.,Fuller Margaret T.,White-Cooper HelenORCID,Matunis Erika L.,DiNardo StephenORCID,Galenza Anthony,O’Brien Lucy Erin,Dow Julian A. T.,Jasper Heinrich,Oliver Brian,Perrimon Norbert,Deplancke Bart,Quake Stephen R.,Luo Liqun,Aerts SteinORCID,

Abstract

AbstractThe ability to obtain single cell transcriptomes for stable cell types and dynamic cell states is ushering in a new era for biology. We created the Tabula Drosophilae, a single cell atlas of the adult fruit fly which includes 580k cells from 15 individually dissected sexed tissues as well as the entire head and body. Over 100 researchers from the fly community contributed annotations to >250 distinct cell types across all tissues. We provide an in-depth analysis of cell type-related gene signatures and transcription factor markers, as well as sexual dimorphism, across the whole animal. Analysis of common cell types that are shared between tissues, such as blood and muscle cells, allowed the discovery of rare cell types and tissue-specific subtypes. This atlas provides a valuable resource for the entire Drosophila community and serves as a comprehensive reference to study genetic perturbations and disease models at single cell resolution.

Publisher

Cold Spring Harbor Laboratory

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