F1F0 ATP Hydrolysis is a Determinant of Metabolic Rate, a Correlate of Lifespan, and a Weakness of Cancer-Reference-Cited by-同舟云学术

F1F0 ATP Hydrolysis is a Determinant of Metabolic Rate, a Correlate of Lifespan, and a Weakness of Cancer

Published:2021-11-09 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Forrest Michael David^ORCID

Abstract

ABSTRACTDramatic rectal temperature decrease, in mice administered with a drug that specifically inhibits F1F0 ATP hydrolysis, suggests that F1F0 ATP hydrolysis is a major determinant of metabolic rate in vivo. Across twelve investigated species, less F1F0 ATP hydrolysis correlates with greater maximal lifespan. Specific drug inhibition of F1F0 ATP hydrolysis exerts potent anti-cancer activity in vitro.

Publisher

Cold Spring Harbor Laboratory

Reference151 articles.

1. Nicholls DG , Ferguson SJ (2002) Bioenergetics 3 (Vol. 3). Gulf Professional Publishing.

2. Modulation of the Oligomerization State of the Bovine F1-ATPase Inhibitor Protein, IF1, by pH

3. Michael David Forrest . “Therapeutic Modulators of the Reverse Mode of ATP Synthase”. U.S. Patent Application No. 16/629,390. Published as US20200306253A1. In PDF format, on the Google Patents website: https://patentimages.storage.googleapis.com/2b/ad/07/f9e06bda62ec75/US20200306253A1.pdf This US patent application is a 371 national entry of PCT/EP2018/069175 (filed 13 July 2018), which published as WO2019/012149A1 (on 17 January 2019).

4. Handling elevates the colonic temperature of mice

5. Human Ageing Genomic Resources: new and updated databases

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. DNA methylation rates scale with maximum lifespan across mammals;Nature Aging;2023-12-04

2. DNA methylation rates scale with maximum lifespan across mammals;2023-05-15