Abstract
AbstractDNA methylation rates have previously been found to broadly correlate with maximum lifespan in mammals, yet no precise relationship has been observed. We developed a statistically robust framework to compare methylation rates at conserved age-related sites across mammals. We found that methylation rates negatively scale with maximum lifespan in both blood and skin. The emergence of explicit scaling suggests that methylation rates are, or are linked to, an evolutionary constraint on maximum lifespan acting across diverse mammalian lineages.
Funder
RCUK | Medical Research Council
University of Edinburgh
T.C. is supported through a Chancellor’s Fellow at the University of Edinburgh and the MRC Human Genetics Unit.
Wellcome Trust
E.L.C. is a cross-disciplinary postdoctoral fellow supported by funding from the University of Edinburgh and the Medical Research Council
Publisher
Springer Science and Business Media LLC
Subject
Neuroscience (miscellaneous),Geriatrics and Gerontology,Aging
Cited by
6 articles.
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