REGN-COV2 antibody cocktail prevents and treats SARS-CoV-2 infection in rhesus macaques and hamsters
Author:
Baum Alina, Copin Richard, Ajithdoss Dharani, Zhou Anbo, Lanza Kathryn, Negron Nicole, Ni Min, Wei Yi, Atwal Gurinder S., Oyejide Adelekan, Goez-Gazi Yenny, Dutton John, Clemmons Elizabeth, Staples Hilary M., Bartley Carmen, Klaffke Benjamin, Alfson Kendra, Gazi Michal, Gonzales Olga, Dick Edward, Carrion Ricardo, Pessaint Laurent, Porto Maciel, Cook Anthony, Brown Renita, Ali Vaneesha, Greenhouse Jack, Taylor Tammy, Andersen Hanne, Lewis Mark G., Stahl Neil, Murphy Andrew J., Yancopoulos George D., Kyratsous Christos A.ORCID
Abstract
AbstractAn urgent global quest for effective therapies to prevent and treat COVID-19 disease is ongoing. We previously described REGN-COV2, a cocktail of two potent neutralizing antibodies (REGN10987+REGN10933) targeting non-overlapping epitopes on the SARS-CoV-2 spike protein. In this report, we evaluate the in vivo efficacy of this antibody cocktail in both rhesus macaques and golden hamsters and demonstrate that REGN-COV-2 can greatly reduce virus load in lower and upper airway and decrease virus induced pathological sequalae when administered prophylactically or therapeutically. Our results provide evidence of the therapeutic potential of this antibody cocktail.
Publisher
Cold Spring Harbor Laboratory
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