Author:
Menze Inga,Bernal Jose,Kaya Pinar,Aki Çağla,Pfister Malte,Geisendörfer Jonas,Yakupov Renat,Heneka Michael T.,Brosseron Frederic,Schmid Matthias C.,Glanz Wenzel,Incesoy Enise I.,Butryn Michaela,Rostamzadeh Ayda,Meiberth Dix,Peters Oliver,Preis Lukas,Lammerding Dominik,Gref Daria,Priller Josef,Spruth Eike J.,Altenstein Slawek,Lohse Andrea,Hetzer Stefan,Schneider Anja,Fliessbach Klaus,Kimmich Okka,Vogt Ina R.,Wiltfang Jens,Bartels Claudia,Schott Björn H.,Hansen Niels,Dechent Peter,Buerger Katharina,Janowitz Daniel,Perneczky Robert,Rauchmann Boris-Stephan,Teipel Stefan,Kilimann Ingo,Goerss Doreen,Laske Christoph,Munk Matthias H.,Sanzenbacher Carolin,Hinderer Petra,Scheffler Klaus,Spottke Annika,Roy-Kluth Nina,Lüsebrink Falk,Neumann Katja,Jessen Frank,Schreiber Stefanie,Düzel Emrah,Ziegler Gabriel
Abstract
AbstractBackgroundPerivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and its exacerbators require further investigation.MethodsWe studied centrum semiovale (CSO) and basal ganglia (BG) PVS computationally over three to four annual visits in 557 participants of the DZNE multicentre DELCODE cohort. We tested volumetric changes of PVS in relation to ageing, sex, years of education, hypertension, AD diagnosis, and cerebrospinal-fluid-derived Amyloid and Tau positivity and interleukin 6 (IL-6).ResultsPVS volumes increased over time. PVS enlargement was associated with baseline white matter hyperintensities. BG-PVS enlargement was related to age and was faster with hypertension. CSO-PVS volumes increased faster with Amyloid and Tau positivity. Higher CSF IL-6 levels predicted PVS volume expansion in both regions and were associated with accelerated PVS enlargement in individuals with Amyloid and Tau positivity.ConclusionOur work supports the region-specific involvement of white matter hyperintensities, neurotoxic waste accumulation, and inflammation in PVS enlargement.
Publisher
Cold Spring Harbor Laboratory