Perivascular spaces in the brain: anatomy, physiology and pathology

Author:

Wardlaw Joanna M.ORCID,Benveniste Helene,Nedergaard Maiken,Zlokovic Berislav V.ORCID,Mestre HumbertoORCID,Lee Hedok,Doubal Fergus N.ORCID,Brown RosalindORCID,Ramirez JoelORCID,MacIntosh Bradley J.ORCID,Tannenbaum AllenORCID,Ballerini LuciaORCID,Rungta Ravi L.,Boido Davide,Sweeney MelanieORCID,Montagne AxelORCID,Charpak Serge,Joutel Anne,Smith Kenneth J.ORCID,Black Sandra E.ORCID,

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference136 articles.

1. Woollam, D. H. & Millen, J. W. The perivascular spaces of the mammalian central nervous system and their relation to the perineuronal and subarachnoid spaces. J. Anat. 89, 193–200 (1955).

2. Smith, A. J., Yao, X., Dix, J. A., Jin, B. J. & Verkman, A. S. Test of the ‘glymphatic’ hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. eLife 6, e27679 (2017).

3. Brown, R. et al. Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovasc. Res. 114, 1462–1473 (2018).

4. Francis, F., Ballerini, L. & Wardlaw, J. M. Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: a systematic review and meta-analysis. Int. J. Stroke 14, 359–371 (2019).

5. Debette, S., Schilling, S., Duperron, M., Larsson, S. & Markus, H. Clinical significance of magnetic resonance imaging markers of vascular brain injury: a systematic review and meta-analysis. JAMA Neurol. 76, 81–94 (2018).

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