Author:
Priesnitz Chantal,Becker Thomas
Abstract
Mitochondria contain their own genome that encodes for a small number of proteins, while the vast majority of mitochondrial proteins is produced on cytosolic ribosomes. The formation of respiratory chain complexes depends on the coordinated biogenesis of mitochondrially encoded and nuclear-encoded subunits. In this review, we describe pathways that adjust mitochondrial protein synthesis and import of nuclear-encoded subunits to the assembly of respiratory chain complexes. Furthermore, we outline how defects in protein import into mitochondria affect nuclear gene expression to maintain protein homeostasis under physiological and stress conditions.
Funder
Deutsche Forschungsgemeinschaft
Sonderforschungsbereich 746
Research Training Group 2202
Excellence Initiative of the German Federal and State Governments
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
72 articles.
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