Abstract
Saccharomyces cerevisiae is widely used as a model organism for eukaryotic cells and generally prefers fermentation rather than respiration even under an aerobic environment. Only when glucose is exhausted, S. cerevisiae switches to aerobic respiration via massive reprogramming of gene expression accompanying that. These gene-expression changes are not simply achieved by the transcriptional level, rather multiple post-transcriptional regulatory steps are also involved. This chapter outlines how budding yeast cells coordinate energy metabolisms based on gene expression, with a focus on the intricate interplay of multiple post-transcriptional regulatory mechanisms. Especially, it includes the roles of RNA-binding proteins as well as non-coding RNAs for post-transcriptional regulations.