Autologous ovarian tissue transplantation and longevity improvement (experimental mice model)

Abstract

AbstractIn the study we showed the improvement in life longevity in mice after step-by step autologous ovarian transplantation. This has proven to be more efficient than “traditional” hormonal replacement therapy. Despite the highest speed and effectiveness of estradiol replacement deficiency in blood by its oral or transdermal use, one did not receive a significant increase in the life longevity in animals and possibly in women (Canderelli R., Leccesse L. et al. 2007). The function of transplanted fragment is usually limited to 6-12 months. This is enough for oncofertility purposes, sometimes, but not for longevity improvement. We performed periodical tissue return (autologous transplantation), containing both cortex and medulla in mice experimental model, that resulted in statistically reliable improvement of longevity. The experimental model we suggested could be projected and to other mammals or humans, as the cortical transplantation gives the same results for reproduction restoration in mice and humans and even on hormone levels normalization, but there is still lack of information about anti-ageing factors containing in ovarian medulla and cortex. That is why we consider that the most important factor for anti-ageing transplantation technology is to preserve both medulla and cortex.SummaryStep-by step autologous ovarian transplantation provides the improvement in life longevity in female mice. This technology could be even more efficient, compared to estrogen hormonal replacement therapy in hormone levels improvement (FSH, estradiol). While menopausal hormonal therapy (MHT) with estrogens doesn’t improve longevity in mice, step-by-step autologous transplantation of ovarian cryopreserved tissue statistically reliably prolongs lifespan in mice.