Affiliation:
1. Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143–0448, USA.
Abstract
The germ line of the nematode
Caenorhabditis elegans
influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.
Publisher
American Association for the Advancement of Science (AAAS)
Reference32 articles.
1. Signals from the reproductive system regulate the lifespan of C. elegans
2. Life-spans were determined at 20°C or at 25°C (when noted) as described (1 11). Animals that crawled off the plates exploded or less frequently died as a “bag of worms” were censored at the last day they were seen alive and were incorporated in the data set until that date as described (27). Survival curves mean life-spans and P values were calculated nonparametrically; log-rank tests were used to assess the similarity between each two groups using Statview 4.5 software (Abacus).
3. Strome S., Martin P., Schierenberg E., Paulsen J., Development 121, 2961 (1995).
4. Tax F. E., Yeargers J. J., Thomas J. H., Nature 368, 150 (1994).
5. Henderson S. T., Gao D., Lambie E. J., Kimble J., Development 120, 2913 (1994).
Cited by
432 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献