Abstract
AbstractAn oxygen sensor-mounted fine-needle biopsy tool was used forin vivomeasurement of oxygen levels in tumor xenografts. The system provides a means of measuring the oxygen content in harvested tumor tissue from specific locations. Oxygen in human tumor xenografts in a murine model was observed for over 1 min. Tissues were mapped in relation to oxygen tension (pO2) readings and sampled for conventional cytological examination. Careful modeling of the pO2readings over 60 seconds yielded a diffusion coefficient for oxygen at the sensor tip, providing additional diagnostic information about the tissue before sampling. Oxygen level measurement may provide a useful adjunct to the use of biomarkers in tumor diagnosis.
Publisher
Cold Spring Harbor Laboratory
Reference37 articles.
1. John M. Eisenberg Center for Clinical Decisions and Communications Science. Core-Needle Biopsy for Breast Abnormalities. In: Comparative Effectiveness Review Summary Guides for Clinicians. AHRQ Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality (US); 2007. Accessed June 9, 2021. http://www.ncbi.nlm.nih.gov/books/NBK368367/
2. Current research status of tumor cell biomarker detection
3. Detection of Hypoxia in Cancer Models: Significance, Challenges, and Advances
4. Abstract 5002: The prognostic relevance and underlying mechanisms of the novel oxygen sensor ADO in cancers
5. Hypoxia and the Tumor Microenvironment