Hypoxia and the Tumor Microenvironment-Reference-Cited by-同舟云学术

Hypoxia and the Tumor Microenvironment

Published:2021-01-01 Issue: Volume:20 Page:153303382110363
ISSN:1533-0346
Container-title:Technology in Cancer Research & Treatment
language:en
Short-container-title:Technol Cancer Res Treat

Author:

Li Yue¹²³⁴^ORCID,Zhao Long¹³⁴,Li Xiao-Feng¹³⁴

Affiliation:

1. Department of Nuclear Medicine, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong, China

2. The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China

3. Clinical Medicine Postdoctoral Research Station, Jinan University, Guangzhou, Guangdong, China

4. Southern University of Science and Technology, Shenzhen, Guangdong, China

Abstract

Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.

Publisher

SAGE Publications

Subject

Cancer Research,Oncology

Link

http://journals.sagepub.com/doi/pdf/10.1177/15330338211036304

Reference92 articles.

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3. Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

4. Hypoxia in cancer: significance and impact on clinical outcome

5. Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment

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