Author:
Li Wentian,Stolovitzky Gustavo,Bernaola-Galván Pedro,Oliver José L.
Abstract
The heterogeneity within, and similarities between, yeast chromosomes are studied. For the former, we show by the size distribution of domains, coding density, size distribution of open reading frames, spatial power spectra, and deviation from binomial distribution for C + G% in large moving windows that there is a strong deviation of the yeast sequences from random sequences. For the latter, not only do we graphically illustrate the similarity for the above mentioned statistics, but we also carry out a rigorous analysis of variance (ANOVA) test. The hypothesis that all yeast chromosomes are similar cannot be rejected by this test. We examine the two possible explanations of this interchromosomal uniformity: a common origin, such as genome-wide duplication (polyploidization), and a concerted evolutionary process.
Publisher
Cold Spring Harbor Laboratory
Subject
Genetics(clinical),Genetics
Reference68 articles.
1. An overabundance of long oligopurine tracts occurs in the genome of simple and complex eukaryotes
2. Compositional segmentation and long-range fractal correlations in DNA sequences
3. THE ISOCHORE ORGANIZATION OF THE HUMAN GENOME
4. THE HUMAN GENOME: Organization and Evolutionary History
5. Boeke J.D. Sandmeyer S.B. (1991) Yeast transposable elements. in The molecular and cellular biology of the yeast Saccharomyces: Vol. I. Genome dynamics, protein synthesis, and energetics, eds Broach J.R. Pringle J.R. Jones E.W. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY), pp 193–261.
Cited by
60 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献