Abstract
AbstractIn humans the skin is a primary thermoregulatory organ, with vasodilation leading to rapid body cooling, whereas in Rodentia the tail performs an analogous function. Many thermodetection mechanisms are likely to be involved including thermosensitive TRPV4 ion channels. Previous studies have shown that TRPV4 can act as a vasodilator by local action in blood vessels, and in this study we investigated whether there was a constitutive role for TRPV4 in mus muscularis tail vascular tone and thermoregulation.We measured tail blood flow and other cardiovascular parameters by pressure plethysmography in lightly sedated CD-1 mice at a range of ambient temperatures, with and without intraperitoneal administration of the blood brain barrier crossing TRPV4 antagonist GSK2193874.As expected for a thermoregulatory organ, we found that tail blood flow increased with temperature. However, unexpectedly we found that the TRPV4 antagonist GSK2193874 increased tail blood flow.Since arterial TRPV4 activation is known to cause vasodilation that would increase tail blood flow, these data suggest that increases in tail blood flow resulting from the TRPV4 antagonist must arise from a site other than the blood vessels themselves, perhaps in central cardiovascular control centres such as the hypothalamus.
Publisher
Cold Spring Harbor Laboratory
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献