Author:
Randad Pranay R.,Pisanic Nora,Kruczynski Kate,Howard Tyrone,Rivera Magdielis Gregory,Spicer Kristoffer,Antar Annukka A.R.,Penson Tristan,Thomas David L.,Pekosz Andrew,Ndahiro Nelson,Aliyu Lateef,Betenbaugh Michael J.,Manley Hannah,Detrick Barbara,Katz Morgan,Cosgrove Sara,Rock Clare,Zyskind Israel,Silverberg Jonathan I.,Rosenberg Avi Z.,Duggal Priya,Manabe Yukari C.,Collins Matthew H.,Heaney Christopher D.
Abstract
ABSTRACTWe evaluated the durability of IgG responses specific to SARS-CoV-2 nucleocapsid (N), receptor binding domain (RBD), and spike (S) antigens in saliva up to 8 months after RT-PCR-confirmed COVID-19 using a multiplex salivary assay. We estimated a half-life of 64 days (d) (95% CI: 49, 80 d) for N, 100 d for RBD (95% CI: 58, 141 d), and 148 d (95% CI: 62, 238 d) for S IgG responses in saliva, consistent with half-life estimates previously reported in blood. Saliva can serve as an alternative to blood to monitor humoral immune responses on a large scale following SARS-CoV-2 infection and vaccination for surveillance and assessment of population immunity.
Publisher
Cold Spring Harbor Laboratory