Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex-Reference-Cited by-同舟云学术

Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex

Published:2021-04-01 Issue: Volume: Page:
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Author:

Campagnola Luke^ORCID,Seeman Stephanie C^ORCID,Chartrand Thomas^ORCID,Kim Lisa^ORCID,Hoggarth Alex^ORCID,Gamlin Clare^ORCID,Ito Shinya^ORCID,Trinh Jessica^ORCID,Davoudian Pasha^ORCID,Radaelli Cristina,Kim Mean-Hwan^ORCID,Hage Travis^ORCID,Braun Thomas^ORCID,Alfiler Lauren^ORCID,Andrade Juia,Bohn Phillip,Dalley Rachel^ORCID,Henry Alex,Kebede Sara^ORCID,Mukora Alice^ORCID,Sandman David,Williams Grace^ORCID,Larsen Rachael,Teeter Corinne,Daigle Tanya L.^ORCID,Berry Kyla,Dotson Nadia,Enstrom Rachel^ORCID,Gorham Melissa,Hupp Madie^ORCID,Lee Samuel Dingman,Ngo Kiet,Nicovich Rusty^ORCID,Potekhina Lydia^ORCID,Ransford Shea,Gary Amanda^ORCID,Goldy Jeff^ORCID,McMillen Delissa^ORCID,Pham Trangthanh^ORCID,Tieu Michael^ORCID,Siverts La’Akea^ORCID,Walker Miranda^ORCID,Farrell Colin^ORCID,Schroedter Martin,Slaughterbeck Cliff^ORCID,Cobb Charles^ORCID,Ellenbogen Richard^ORCID,Gwinn Ryder P^ORCID,Keene C. Dirk,Ko Andrew L,Ojemann Jeffrey G^ORCID,Silbergeld Daniel L,Carey Daniel^ORCID,Casper Tamara^ORCID,Crichton Kirsten^ORCID,Clark Michael^ORCID,Dee Nick^ORCID,Ellingwood Lauren^ORCID,Gloe Jessica^ORCID,Kroll Matthew^ORCID,Sulc Josef^ORCID,Tung Herman^ORCID,Wadhwani Katherine^ORCID,Brouner Krissy^ORCID,Egdorf Tom^ORCID,Maxwell Michelle^ORCID,McGraw Medea^ORCID,Pom Christina Alice^ORCID,Ruiz Augustin^ORCID,Bomben Jasmine^ORCID,Feng David^ORCID,Hejazinia Nika^ORCID,Shi Shu,Szafer Aaron^ORCID,Wakeman Wayne^ORCID,Phillips John,Bernard Amy^ORCID,Esposito Luke,D’Orazi Florence D,Sunkin Susan^ORCID,Smith Kimberly^ORCID,Tasic Bosiljka^ORCID,Arkhipov Anton^ORCID,Sorensen Staci^ORCID,Lein Ed^ORCID,Koch Christof^ORCID,Murphy Gabe^ORCID,Zeng Hongkui^ORCID,Jarsky Tim^ORCID

Abstract

AbstractTo elucidate cortical microcircuit structure and synaptic properties we present a unique, extensive, and public synaptic physiology dataset and analysis platform. Through its application, we reveal principles that relate cell type to synapse properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Despite these associations, synaptic properties are heterogeneous in most subclass to subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, while the strength axis accounts for significant heterogeneity within the subclass. In human cortex, excitatory to excitatory synapse dynamics are distinct from those in mouse and short-term plasticity varies with depth across layers 2 and 3. With a novel connectivity analysis that enables fair comparisons between circuit elements, we find that intralaminar connection probability among cell subclasses exhibits a strong layer dependence.These and other findings combined with the analysis platform create new opportunities for the neuroscience community to advance our understanding of cortical microcircuits.

Publisher

Cold Spring Harbor Laboratory

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