Author:
Nasu Yusuke,Murphy-Royal Ciaran,Wen Yurong,Haidey Jordan,Molina M. Rosana S.,Aggarwal Abhi,Zhang Shuce,Kamijo Yuki,Paquet Marie-Eve,Podgorski Kaspar,Drobizhev Mikhail,Bains Jaideep S.,Joanne Lemieux M.,Gordon Grant R.,Campbell Robert E.
Abstract
AbstractTo enable investigations of the emerging roles of cell-to-cell shuttling of L-lactate, we have developed an intensiometric green fluorescent genetically encoded biosensor for extracellular L-lactate. We demonstrate that this biosensor, designated eLACCO1.1, enables minimally invasive cellular resolution imaging of extracellular L-lactate in cultured mammalian cells and brain tissue.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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