Author:
Dudley A T,Lyons K M,Robertson E J
Abstract
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Reference66 articles.
1. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl eds. 1987. Ribonuclease protection assay. In Current protocols in molecular biology, pp. 4.7.1. John Wiley & Sons/Greene, New York.
2. Bradley, A. 1987. Production and analysis of chimeric mice. In Teratocarcinomas and embryonic stem cells; a practical approach ed. E.J. Robertson, pp. 131–151. IRL Press, Oxford, UK.
3. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
4. Studies on an anophthalmic strain of mice I. Embryology of the eye region
5. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Cited by
1013 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献