Author:
Shantier Shaza W.,Elmansi Hashim E.,Elnnewery Mihad E.,Osman Hind K.,Alhassan Isam-Aldin A.,Abdelrhman Fatima A.,Yagaub Ahmed A.,Yousif Einas M.,Abdalla Alaa I.,Elamin Rawan A.,Fadol Howina S.,Fadl Alla Afra A.,Hassan Mohamed A.
Abstract
AbstractBackgroundTAL1is a proto-oncogene whose distorted modifications in committed T-cell Precursors is related with the development of T-ALL, it also found to be related to many other human hematological diseases such as lymphoblastic lymphoma, immunodeficiency 18, acute myeloid leukemia and diamond-blackfan Anemia.ObjectivesThis study aims to predict the effect of nsSNPs onTAL1protein structure functionMethodsRetrieved nSNPs in the coding and3’UTRregions were analyzed using different in silico tools. Interactions ofTAL1with functionally similar genes were investigated using Genemania. Post-translational modifications in several sites of the protein were also investigated.ResultsOut of ninety nsSNPs identified, only eight were found damaging to protein function of which one is located in the basis helix-loop-helix domain (bHLH). Two SNPs were anticipated by PolymiRTs to prompt disturbance or creation of miR binding sites.ConclusionThe present study is the first ever computational analysis ofTAL1’s nsSNPs hence this effort might be of help in the near future for inventing early diagnostic and therapeutic measures for T-ALL
Publisher
Cold Spring Harbor Laboratory
Reference52 articles.
1. ((AML): Practice Essentials, Pathophysiology, Etiology. [online] Emedicine.medscape.com. Available at: http://emedicine.medscape.com/article/197802-overview [Accessed 21 Apr. 2018].
2. Disease-ontology. Acute leukemia. [online] Available at: http://disease-ontology.org/term/DOID%3A12603/ [Accessed 8 May 2018].
3. Acute Lymphoblastic Leukemia;Clinics in Laboratory Medicine,2011
4. Orpha. TAL1TAL bHLH transcription factor 1, erythroid differentiation factor [online] Available at http://www.orpha.net/consor/cgi-bin/Disease_Genes.php?lng=EN&data_id=15576 [Accessed 31 May 2018]
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