Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control-Reference-Cited by-同舟云学术

Improved Aedes aegypti mosquito reference genome assembly enables biological discovery and vector control

Published:2017-12-29 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Matthews Benjamin J.^ORCID,Dudchenko Olga^ORCID,Kingan Sarah^ORCID,Koren Sergey^ORCID,Antoshechkin Igor^ORCID,Crawford Jacob E.^ORCID,Glassford William J.^ORCID,Herre Margaret^ORCID,Redmond Seth N.^ORCID,Rose Noah H.^ORCID,Weedall Gareth D.^ORCID,Wu Yang^ORCID,Batra Sanjit S.^ORCID,Brito-Sierra Carlos A.^ORCID,Buckingham Steven D.^ORCID,Campbell Corey L^ORCID,Chan Saki^ORCID,Cox Eric^ORCID,Evans Benjamin R.^ORCID,Fansiri Thanyalak^ORCID,Filipović Igor^ORCID,Fontaine Albin^ORCID,Gloria-Soria Andrea^ORCID,Hall Richard^ORCID,Joardar Vinita S.^ORCID,Jones Andrew K.^ORCID,Kay Raissa G.G.^ORCID,Kodali Vamsi K.^ORCID,Lee Joyce^ORCID,Lycett Gareth J.^ORCID,Mitchell Sara N.^ORCID,Muehling Jill^ORCID,Murphy Michael R.^ORCID,Omer Arina D.^ORCID,Partridge Frederick A.^ORCID,Peluso Paul^ORCID,Aiden Aviva Presser^ORCID,Ramasamy Vidya^ORCID,Rašić Gordana^ORCID,Roy Sourav^ORCID,Saavedra-Rodriguez Karla^ORCID,Sharan Shruti^ORCID,Sharma Atashi^ORCID,Smith Melissa Laird^ORCID,Turner Joe^ORCID,Weakley Allison M.^ORCID,Zhao Zhilei^ORCID,Akbari Omar S.^ORCID,Black William C.^ORCID,Cao Han^ORCID,Darby Alistair C.^ORCID,Hill Catherine^ORCID,Johnston J. Spencer^ORCID,Murphy Terence D.^ORCID,Raikhel Alexander S.^ORCID,Sattelle David B.^ORCID,Sharakhov Igor V.^ORCID,White Bradley J.^ORCID,Zhao Li^ORCID,Aiden Erez Lieberman^ORCID,Mann Richard S.^ORCID,Lambrechts Louis^ORCID,Powell Jeffrey R.^ORCID,Sharakhova Maria V.^ORCID,Tu Zhijian^ORCID,Robertson Hugh M.^ORCID,McBride Carolyn S.^ORCID,Hastie Alex R.^ORCID,Korlach Jonas^ORCID,Neafsey Daniel E.^ORCID,Phllippy Adam M.^ORCID,Vosshall Leslie B.^ORCID

Abstract

Female Aedes aegypti mosquitoes infect hundreds of millions of people each year with dangerous viral pathogens including dengue, yellow fever, Zika, and chikungunya. Progress in understanding the biology of this insect, and developing tools to fight it, has been slowed by the lack of a high-quality genome assembly. Here we combine diverse genome technologies to produce AaegL5, a dramatically improved and annotated assembly, and demonstrate how it accelerates mosquito science and control. We anchored the physical and cytogenetic maps, resolved the size and composition of the elusive sex-determining “M locus”, significantly increased the known members of the glutathione-S-transferase genes important for insecticide resistance, and doubled the number of chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites. Using high-resolution QTL and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. We predict that AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly arboviral vector.

Publisher

Cold Spring Harbor Laboratory

Reference151 articles.

1. The global distribution and burden of dengue

2. Challenges with mosquito-borne viral diseases: Outbreak of the monsters;Curr Top Med Chem,2017

3. Genome Sequence of Aedes aegypti , a Major Arbovirus Vector

4. An Integrated Linkage, Chromosome, and Genome Map for the Yellow Fever Mosquito Aedes aegypti

5. De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evolution of fibrinogen domain related proteins in Aedes aegypti: Their expression during Arbovirus infections;Gene Reports;2021-06

2. Broad dengue neutralization in mosquitoes expressing an engineered antibody;PLOS Pathogens;2020-01-16

3. Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti;Bioorganic & Medicinal Chemistry;2020-01

4. Broad Dengue Neutralization in Mosquitoes Expressing an Engineered Antibody;2019-05-24

5. Engineered resistance to Zika virus in transgenic Aedes aegypti expressing a polycistronic cluster of synthetic small RNAs;Proceedings of the National Academy of Sciences;2019-02-05