Genome Sequence of
Aedes aegypti
, a Major Arbovirus Vector
Author:
Nene Vishvanath12345, Wortman Jennifer R.12345, Lawson Daniel12345, Haas Brian12345, Kodira Chinnappa12345, Tu Zhijian (Jake)12345, Loftus Brendan12345, Xi Zhiyong12345, Megy Karyn12345, Grabherr Manfred12345, Ren Quinghu12345, Zdobnov Evgeny M.12345, Lobo Neil F.12345, Campbell Kathryn S.12345, Brown Susan E.12345, Bonaldo Maria F.12345, Zhu Jingsong12345, Sinkins Steven P.12345, Hogenkamp David G.12345, Amedeo Paolo12345, Arensburger Peter12345, Atkinson Peter W.12345, Bidwell Shelby12345, Biedler Jim12345, Birney Ewan12345, Bruggner Robert V.12345, Costas Javier12345, Coy Monique R.12345, Crabtree Jonathan12345, Crawford Matt12345, deBruyn Becky12345, DeCaprio David12345, Eiglmeier Karin12345, Eisenstadt Eric12345, El-Dorry Hamza12345, Gelbart William M.12345, Gomes Suely L.12345, Hammond Martin12345, Hannick Linda I.12345, Hogan James R.12345, Holmes Michael H.12345, Jaffe David12345, Johnston J. Spencer12345, Kennedy Ryan C.12345, Koo Hean12345, Kravitz Saul12345, Kriventseva Evgenia V.12345, Kulp David12345, LaButti Kurt12345, Lee Eduardo12345, Li Song12345, Lovin Diane D.12345, Mao Chunhong12345, Mauceli Evan12345, Menck Carlos F. M.12345, Miller Jason R.12345, Montgomery Philip12345, Mori Akio12345, Nascimento Ana L.12345, Naveira Horacio F.12345, Nusbaum Chad12345, O'Leary Sinéad12345, Orvis Joshua12345, Pertea Mihaela12345, Quesneville Hadi12345, Reidenbach Kyanne R.12345, Rogers Yu-Hui12345, Roth Charles W.12345, Schneider Jennifer R.12345, Schatz Michael12345, Shumway Martin12345, Stanke Mario12345, Stinson Eric O.12345, Tubio Jose M. C.12345, VanZee Janice P.12345, Verjovski-Almeida Sergio12345, Werner Doreen12345, White Owen12345, Wyder Stefan12345, Zeng Qiandong12345, Zhao Qi12345, Zhao Yongmei12345, Hill Catherine A.12345, Raikhel Alexander S.12345, Soares Marcelo B.12345, Knudson Dennis L.12345, Lee Norman H.12345, Galagan James12345, Salzberg Steven L.12345, Paulsen Ian T.12345, Dimopoulos George12345, Collins Frank H.12345, Birren Bruce12345, Fraser-Liggett Claire M.12345, Severson David W.12345
Affiliation:
1. The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. 2. European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. 3. Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02141, USA. 4. Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. 5. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Abstract
We present a draft sequence of the genome of
Aedes aegypti
, the primary vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the genome of the malaria vector
Anopheles gambiae
. Nearly 50% of the
Ae. aegypti
genome consists of transposable elements. These contribute to a factor of ∼4 to 6 increase in average gene length and in sizes of intergenic regions relative to
An. gambiae
and
Drosophila melanogaster
. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of ∼2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to
An. gambiae
suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference39 articles.
1. Biology of Disease Vectors 1996 2. (L.): The Yellow Fever Mosquito Its Life History Bionomics and Structure 1960 3. The Biology of Mosquitoes 1992 4. GENETIC AND PHYSICAL MAPPING IN MOSQUITOES: Molecular Approaches 5. Yellow Fever: The Recurring Plague
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