Abstract
AbstractPrediction of snail PAX group proteins inLisachatina fulicawas performed. For this this purpose, homologous sequences to already known PAX proteins ofCephalopoda, GastropodaandBivalviamolluscs were predicted. The presence of certain domains (Paired box, Homeodomain and octapeptide) in the structure of the primary predicted sequences ofLisachatina fulicaproteins from the GigaDB was analyzed. Also, to confirm that the sequences found belong to the PAX family proteins, their secondary and 3D structures were predicted, and their DNA-binding capacity was compared to the control Paired box domain using molecular docking. As a result, 8 proteins ofLisachatina fulicacontaining PAX characteristic sequences were identified. Based on the results of domain structure search and phylogenetic analysis, the proteins were categorized into 5 subfamilies of PAX proteins, namely I, III, IV, β, and Pox-Neuro. The result provides a starting point for the search for the functional role of PAX proteins in theLisachatina fulica.
Publisher
Cold Spring Harbor Laboratory