Author:
Gu Se Hun,Yu Chi Ho,Song Youngjo,Kim Na Young,Sim Euni,Choi Jun Young,Song Dong Hyun,Hur Gyeung Haeng,Shin Young Kee,Jeong Seong Tae
Abstract
AbstractA small interfering RNA (siRNA) inhibitors have demonstrated the novel modality for suppressing infectious diseases. Sixty-one siRNA molecules, predicted by the bioinformatics programs, were screened for the possibility of treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using an in vitro plaque assay. Among six siRNA leads with the efficacy of reducing plaque number, the siRNA targeting RNA-dependent RNA polymerase (RdRp) showed a reduction in SARS-CoV-2 infection-induced fever and virus titer in the Golden Syrian hamster and rhesus macaque. These results suggest the potential for RdRp targeting siRNA as a new treatment for the coronavirus disease 2019 (COVID-19).
Publisher
Cold Spring Harbor Laboratory
Cited by
9 articles.
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