Author:
Kopec Ashley M.,Carew Thomas J.
Abstract
Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g., Ras–MEK–MAPK) to mediate overlapping functional endpoints. Several GFs have been implicated in memory formation, but due to a high level of convergent signaling, the unique contributions of individual GFs as well as the interactions between GF signaling cascades during the induction of memory is not well known. In this review, we highlight the unique roles of specific GFs in dendritic plasticity, and discuss the spatial and temporal profiles of different GFs during memory formation. Collectively, the data suggest that the roles of GF signaling in long-lasting behavioral and structural plasticity may be best viewed as interactive components in a complex molecular network.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Reference156 articles.
1. Epidermal growth-factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices;Brain Res,1991
2. At a PI3K crossroads: Lessons from flies and rodents;Rev Neurosci,2012
3. Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory
4. MAPK regulation of gene expression in the central nervous system;Acta Neurobiol Exp (Wars),2000
5. Activin plays a key role in the maintenance of long-term memory and late-LTP
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