Author:
Ntranos Vasilis,Yi Lynn,Melsted Páll,Pachter Lior
Abstract
AbstractSingle-cell RNA-Seq makes it possible to characterize the transcriptomes of cell types and identify their transcriptional signatures via differential analysis. We present a fast and accurate method for discriminating cell types that takes advantage of the large numbers of cells that are assayed. When applied to transcript compatibility counts obtained via pseudoalignment, our approach provides a quantification-free analysis of 3’ single-cell RNA-Seq that can identify previously undetectable marker genes.
Publisher
Cold Spring Harbor Laboratory
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