Comparative Nephro-Hepatoprotective Effects of Herbal Teas fromHibiscus sabdariffa, Moringa oleifera, Zingiber officinale, and Azadirachta indicain Alloxan-Induced Diabetic Male Wistar Rats: A Preclinical Study

Abstract

AbstractDiabetes, a silent killer, ravages the kidney and liver, leaving a trail of destruction in its wake. Studies have suggested a linkconnectingdysfunctional liver and renalactivity along side glucotoxicretinopathy in patients of type 2 diabetes mellitus. Against this background, our preclinical study unveils the remarkable nephro-hepatoprotective effects of herbal teas fromHibiscus sabdariffa, Moringa oleifera, Zingiber officinale, and Azadirachta indicain diabetic male Wistar rats induced with alloxan.Diabetes of artificial source was administered through a one-time interperitonealadministeration of about seven categorieshaving 6 rats in the individual group.control (glycemic), diabetic groupthat is made up of alloxan treatment + Zobo (100+400 mg/kg)., alloxan + moringa (100 +200 mg/kg), alloxan + ginger (100+500 mg/kg), alloxan + Dogoyaro (100+250 mg/kg), and lastly, the alloxan +glibenclamide(100+5mg/kg) were orally given for 28 days.Reduction of tissue weight was observed upon administration of alloxan which was ameliorated upon treatment with the selected herbal teas. Also, elevated levels of liver and kidney biomakersinduced by alloxan were reversed upon administration of the Herbal teas. Furthermore, the Herbal teas decreased fasting blood glucose, which was initially significantly increased byalloxan (p<0.05). Consequently, given to their antihyperglycemic and nephro-hepatoprotective prowess, these selected herbal teas offer a beacon of hope for the millions afflicted not just with diabetes but also diabetes-related kidney and liver diseases.