Olfactory combinatorial coding supports risk-reward decision making inC. elegans

Author:

Saad Md Zubayer Hossain,Ryan William G.,Edwards C. Autumn,Szymanski Benjamin N.,Marri Aryan R.,Jerow Lilian G.,McCullumsmith Robert,Bamber Bruce A.

Abstract

AbstractVertebrate and insect olfactory systems generate diversity in odor perception using combinatorial coding, where individual odorant molecules activate unique but overlapping sets of olfactory receptor neurons. It is not well understood how these patterns are decoded and transformed into downstream physiological responses. Here, we demonstrate thatCaenorhabditis elegansuses combinatorial coding to formulate locomotory responses to the odorant 1-octanol (1-oct). Whole-network Ca++imaging showed that 1-oct is encoded combinatorially, activating multiple sensory neurons including ASH and AWC, associated with repulsion and attraction, respectively. The temporal dynamics of these neuronal activations indicate that 1-oct stimulates attractive and repulsive afferent pathways simultaneously; altering the relative strengths of these pathways is sufficient to convert 1-oct from a repellent to an attractant in microfluidics-based behavioral assays. These results identify the balance between attraction and repulsion as a key factor determining chemotactic behavior, achieved through modulation of locomotory reversals and speed. At the circuit level, the attractive and repulsive pathways can both entrain the activity of the reverse command interneuron AVA, a key regulator of reversals, with the stronger pathway predominating. This coding strategy facilitates context-dependent modulation of sensory responses. 1-oct is present in decaying plant material, signaling the possible presence of bacterial food. However, 1-oct is also toxic, and therefore represents a high risk food signal. Adding a different food signal (representing better food in a different location) suppresses the 1-oct attraction pathway by depressing AWC activity, tips the sensory balance toward the aversive pathway, and converts 1-oct attraction into 1-oct repulsion.

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3