Abstract
SUMMARYBuilding a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is notoriously difficult even when the adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds to subtle environmental shifts and then modeling the number of phenotypes they must collectively influence by decomposing these patterns of fitness variation. We find that a small number of phenotypes predicts fitness of the adaptive mutations near their original glucose-limited evolution condition. Importantly, phenotypes that matter little to fitness at or near the evolution condition can matter strongly in distant environments. This suggests that adaptive mutations are locally modular—affecting a small number of phenotypes that matter to fitness in the environment where they evolved—yet globally pleiotropic—affecting additional phenotypes that may reduce or improve fitness in new environments.
Publisher
Cold Spring Harbor Laboratory
Reference104 articles.
1. Aggeli, D. , Li, Y. , Sherlock, G. , 2020. Changes in the distribution of fitness effects and adaptive mutational spectra following a single first step towards adaptation (preprint). Evolutionary Biology. https://doi.org/10.1101/2020.06.12.148833
2. Altenberg, L. , 2005. Modularity in Evolution: Some Low-Level Questions, in: Modularity: Understanding the Development and Evolution of Complex Natural Systems. MIT Press, p. 32.
3. Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing;Cell,2019
4. Comprehensive Characterization of Cancer Driver Genes and Mutations
5. Barghi, N. , Hermisson, J. , Schlötterer, C. , 2020. Polygenic adaptation: a unifying framework to understand positive selection. Nat. Rev. Genet. https://doi.org/10.1038/s41576-020-0250-z
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献