Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization

Author:

Ling King-Hwa,Rajandream Marie-Adele,Rivailler Pierre,Ivens Alasdair,Yap Soon-Joo,Madeira Alda M.B.N.,Mungall Karen,Billington Karen,Yee Wai-Yan,Bankier Alan T.,Carroll Fionnadh,Durham Alan M.,Peters Nicholas,Loo Shu-San,Mat Isa Mohd Noor,Novaes Jeniffer,Quail Michael,Rosli Rozita,Nor Shamsudin Mariana,Sobreira Tiago J.P.,Tivey Adrian R.,Wai Siew-Fun,White Sarah,Wu Xikun,Kerhornou Arnaud,Blake Damer,Mohamed Rahmah,Shirley Martin,Gruber Arthur,Berriman Matthew,Tomley Fiona,Dear Paul H.,Wan Kiew-Lian

Abstract

Eimeria tenella is an intracellular protozoan parasite that infects the intestinal tracts of domestic fowl and causes coccidiosis, a serious and sometimes lethal enteritis. Eimeria falls in the same phylum (Apicomplexa) as several human and animal parasites such as Cryptosporidium, Toxoplasma, and the malaria parasite, Plasmodium. Here we report the sequencing and analysis of the first chromosome of E. tenella, a chromosome believed to carry loci associated with drug resistance and known to differ between virulent and attenuated strains of the parasite. The chromosome—which appears to be representative of the genome—is gene-dense and rich in simple-sequence repeats, many of which appear to give rise to repetitive amino acid tracts in the predicted proteins. Most striking is the segmentation of the chromosome into repeat-rich regions peppered with transposon-like elements and telomere-like repeats, alternating with repeat-free regions. Predicted genes differ in character between the two types of segment, and the repeat-rich regions appear to be associated with strain-to-strain variation.

Publisher

Cold Spring Harbor Laboratory

Subject

Genetics(clinical),Genetics

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