Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Author:
Han Lei, Wei Xiaoyu, Liu Chuanyu, Volpe GiacomoORCID, Zhuang Zhenkun, Zou Xuanxuan, Wang Zhifeng, Pan Taotao, Yuan Yue, Zhang Xiao, Fan Peng, Guo Pengcheng, Lai Yiwei, Lei Ying, Liu Xingyuan, Yu Feng, Shangguan Shuncheng, Lai Guangyao, Deng Qiuting, Liu Ya, Wu Liang, Shi Quan, Yu Hao, Huang Yunting, Cheng Mengnan, Xu Jiangshan, Liu Yang, Wang Mingyue, Wang Chunqing, Zhang Yuanhang, Xie Duo, Yang Yunzhi, Yu Yeya, Zheng Huiwen, Wei Yanrong, Huang Fubaoqian, Lei Junjie, Huang Waidong, Zhu Zhiyong, Lu Haorong, Wang Bo, Wei Xiaofeng, Chen Fengzhen, Yang Tao, Du Wensi, Chen Jing, Xu Shibo, An Juan, Ward Carl, Wang Zongren, Pei Zhong, Wong Chi-Wai, Liu Xiaolei, Zhang Huafeng, Liu Mingyuan, Qin Baoming, Schambach Axel, Isern Joan, Feng Liqiang, Liu Yan, Guo Xiangyu, Liu Zhen, Sun Qiang, Maxwell Patrick H., Barker Nick, Muñoz-Cánoves Pura, Gu YingORCID, Mulder Jan, Uhlen Mathias, Tan Tao, Liu Shiping, Yang Huanming, Wang Jian, Hou Yong, Xu Xun, Esteban Miguel A., Liu Longqi
Abstract
Studying tissue composition and function in non-human primates (NHP) is crucial to understand the nature of our own species. Here, we present a large-scale single-cell and single-nucleus transcriptomic atlas encompassing over one million cells from 43 tissues from the adult NHP Macaca fascicularis. This dataset provides a vast, carefully annotated, resource to study a species phylogenetically close to humans. As proof of principle, we have reconstructed the cell-cell interaction networks driving Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases and intersected our data with human genetic disease orthologous coordinates to identify both expected and unexpected associations. Our Macaca fascicularis cell atlas constitutes an essential reference for future single-cell studies in human and NHP.
Publisher
Cold Spring Harbor Laboratory
|
|