Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

Author:

Borner KatyORCID,Teichmann Sarah A.ORCID,Quardokus Ellen M.ORCID,Gee JamesORCID,Browne KristenORCID,Osumi-Sutherland DavidORCID,Herr Bruce W.ORCID,Bueckle AndreasORCID,Paul HrishikeshORCID,Haniffa Muzlifah A.ORCID,Jardine LauraORCID,Bernard AmyORCID,Ding Song-LinORCID,Miller Jeremy A.ORCID,Lin ShinORCID,Halushka MarcORCID,Boppana AvinashORCID,Longacre Teri A.ORCID,Hickey JohnORCID,Lin YiingORCID,Valerius M. ToddORCID,He YongqunORCID,Pryhuber GloriaORCID,Sun XinORCID,Jorgensen MardaORCID,Radtke AndreaORCID,Wasserfall CliveORCID,Ginty FionaORCID,Ho JonhanORCID,Sunshine JoelORCID,Beuschel Rebecca T.ORCID,Brusko MaiganORCID,Lee SujinORCID,Malhotra RajeevORCID,Jain SanjayORCID,Weber GriffinORCID

Abstract

This paper reviews efforts across 16 international consortia to construct human anatomical structures, cell types, and biomarkers (ASCT+B) tables and three-dimensional reference organs in support of a Human Reference Atlas. We detail the ontological descriptions and spatial three-dimensional anatomical representations together with user interfaces that support the registration and exploration of human tissue data. Four use cases are presented to demonstrate the utility of ASCT+B tables for advancing biomedical research and improving health.

Publisher

Cold Spring Harbor Laboratory

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