Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein
Author:
Lapidus Sarah, Liu FeimeiORCID, Casanovas-Massana ArnauORCID, Dai Yile, Huck John D.ORCID, Lucas Carolina, Klein Jon, Filler Renata B., Strine Madison S., Sy Mouhamad, Deme Awa B.ORCID, Badiane Aida S.ORCID, Dieye Baba, Ndiaye Ibrahima Mbaye, Diedhiou Younous, Mbaye Amadou Moctar, Diagne Cheikh TidianeORCID, Vigan-Womas Inés, Mbengue AlassaneORCID, Sadio Bacary D., Diagne Moussa M., Moore Adam J., Mangou Khadidiatou, Diallo Fatoumata, Sene Seynabou D., Pouye Mariama N., Faye Rokhaya, Diouf Babacar, Nery Nivison, Costa Federico, Reis Mitermayer, Muenker M. Catherine, Hodson Daniel Z., Mbarga Yannick, Katz Ben Z., Andrews Jason R.ORCID, Campbell Melissa, Srivathsan Ariktha, Kamath Kathy, Baum-Jones Elisabeth, Faye Ousmane, Sall Amadou Alpha, Vélez Juan Carlos Quintero, Cappello Michael, Wilson Michael, Ben-Mamoun Choukri, Somé Fabrice A., Dabiré Roch K., Moukoko Carole Else Eboumbou, Ouédraogo Jean Bosco, Boum Yap, Shon John, Ndiaye Daouda, Wisnewski Adam, Parikh Sunil, Iwasaki AkikoORCID, Wilen Craig B.ORCID, Ko Albert I.ORCID, Ring Aaron M.ORCID, Bei Amy K.ORCID
Abstract
ABSTRACTIndividuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries.
Publisher
Cold Spring Harbor Laboratory
Cited by
22 articles.
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