Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blood donors

Author:

Uyoga Sophie1ORCID,Adetifa Ifedayo M. O.12ORCID,Karanja Henry K.1ORCID,Nyagwange James1ORCID,Tuju James1ORCID,Wanjiku Perpetual1ORCID,Aman Rashid3,Mwangangi Mercy3,Amoth Patrick3,Kasera Kadondi3ORCID,Ng’ang’a Wangari4ORCID,Rombo Charles5,Yegon Christine5,Kithi Khamisi5,Odhiambo Elizabeth5,Rotich Thomas5ORCID,Orgut Irene5,Kihara Sammy5,Otiende Mark1ORCID,Bottomley Christian2,Mupe Zonia N.1ORCID,Kagucia Eunice W.1ORCID,Gallagher Katherine E.12ORCID,Etyang Anthony1ORCID,Voller Shirine12,Gitonga John N.1,Mugo Daisy1ORCID,Agoti Charles N.1,Otieno Edward1ORCID,Ndwiga Leonard1ORCID,Lambe Teresa6ORCID,Wright Daniel6ORCID,Barasa Edwine1,Tsofa Benjamin1ORCID,Bejon Philip16,Ochola-Oyier Lynette I.1,Agweyu Ambrose1ORCID,Scott J. Anthony G.12,Warimwe George M.16ORCID

Affiliation:

1. KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

2. Department of Infectious Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.

3. Ministry of Health, Government of Kenya, Nairobi, Kenya.

4. Presidential Policy and Strategy Unit, The Presidency, Government of Kenya, Nairobi, Kenya.

5. Kenya National Blood Transfusion Services, Ministry of Health, Nairobi, Kenya.

6. Nuffield Department of Medicine, Oxford University, Oxford, UK.

Abstract

Pandemic progress in Kenya By the end of July 2020, Kenya had reported only 341 deaths and ∼20,000 cases of COVID-19. This is in marked contrast to the tens of thousands of deaths reported in many higher-income countries. The true extent of COVID-19 in the community was unknown and likely to be higher than reports indicated. Uyoga et al. found an overall seroprevalence among blood donors of 4.3%, peaking in 35- to 44-year-old individuals (see the Perspective by Maeda and Nkengasong). The low mortality can be partly explained by the steep demographics in Kenya, where less than 4% of the population is 65 or older. These circumstances combine to result in Kenyan hospitals not currently being overwhelmed by patients with respiratory distress. However, the imposition of a strict lockdown in this country has shifted the disease burden to maternal and child deaths as a result of disruption to essential medical services. Science , this issue p. 79 ; see also p. 27

Funder

Oak Foundation

Wellcome

Medical Research Council

African Academy of Sciences

DFID and Wellcome

NIHR MPRU

Department for International Development

NIHR Health Protection Research Unit in Immunisation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. United Nations Department of Economic and Social Affairs Population Division “World Urbanization Prospects: The 2018 Revision ” custom data acquired via (2018); https://population.un.org/wup/DataQuery.

2. Africa Centres for Diseases Control and Prevention “Coronavirus Disease 2019 (COVID-19)” (2020); https://africacdc.org/covid-19[accessed 21 July 2020].

3. The relatively young and rural population may limit the spread and severity of COVID-19 in Africa: a modelling study

4. Demographic science aids in understanding the spread and fatality rates of COVID-19

5. Ministry of Health Kenya “Press Statement on the update of the coronavirus in the country and response measures” (2020); www.health.go.ke/wp-content/uploads/2020/03/Coronavirus-Press-Statement-March-17-2020.pdf.

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