Abstract
AbstractBackgroundThere is substantial disagreement about whether gluten-free foods should be prescribed on the NHS. We aim to describe time trends, variation and factors associated with prescribing gluten-free foods in England.MethodsWe described long-term national trends in gluten-free prescribing, and practice and Clinical Commissioning Group (CCG) level monthly variation in the rate of gluten-free prescribing (per 1000 patients) over time. We used a mixed effect poisson regression model to determine factors associated with gluten-free prescribing rate.ResultsThere were 1.3 million gluten-free prescriptions between July 2016 and June 2017, down from 1.8 million in 2012/13, with a corresponding cost reduction from £25.4m to £18.7m. There was substantial variation in prescribing rates among practices (range 0 to 148 prescriptions per 1000 patients, interquartile range 7.3 to 31.8), driven in part by substantial variation at the CCG level, likely due to differences in prescribing policy. Practices in the most deprived quintile of deprivation score had a lower prescribing rate than those in the highest quintile (incidence rate ratio 0.89, 95% confidence interval 0.87-0.91). This is potentially a reflection of the lower rate of diagnosed coeliac disease in more deprived populations.ConclusionGluten-free prescribing is in a state of flux, with substantial clinically unwarranted variation between practices and CCGs.Strengths and weaknesses of the studyWe were able to measure the prescribing of gluten-free foods across all prescribing in England, eliminating bias. We also removed seasonal variation by aggregating savings over 12 months.As well as gluten-free prescribing variation at practice and CCG level, we have described long-term prescribing trends at national level, back to 1998.Using the available data, we were unable to look at gluten-free prescribing at prescriber level, or investigate factors associated with prescribing to individual patients
Publisher
Cold Spring Harbor Laboratory
Reference19 articles.
1. Adherence to a Gluten Free Diet Is Associated with Receiving Gluten Free Foods on Prescription and Understanding Food Labelling
2. Should patients with coeliac disease pay for their treatment?
3. Availability of gluten-free foods on NHS prescription - GOV.UK. https://www.gov.uk/government/consultations/availability-of-gluten-free-foods-on-nhs-prescription (accessed 20 Dec 2017).
4. Coeliac disease - NICE CKS. https://cks.nice.org.uk/coeliac-disease (accessed 18 Sep 2017).
5. Gluten-free foods: a revised prescribing guide. Coeliac UK. https://www.coeliac.org.uk/document-library/378-gluten-free-foods-a-revised-prescribing-guide/?return=/gluten-free-diet-and-lifestyle/prescriptions/national-prescribing-guidelines/ (accessed 18 Sep 2017).