Feeding-state dependent modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions inDrosophila

Author:

de Tredern Eloïse,Manceau Dylan,Blanc Alexandre,Sakagiannis Panagiotis,Barre Chloe,Sus Victoria,Viscido Francesca,Hasan Md Amit,Autran Sandra,Nawrot MartinORCID,Masson Jean-BaptisteORCID,Jovanic TihanaORCID

Abstract

AbstractThe feeding state of an animal changes behavioral priorities and thus influences even non-feeding related decisions. How is the influence of the feeding state transmitted to non-feeding related circuits and what are the circuit mechanisms involved in biasing non-feeding related decisions remains an open question. By combining calcium imaging, neuronal manipulations, behavioral analysis and computational modeling we determined that the competitive interactions between different behavioral responses to a mechanical stimulus are biased by the feeding state and found that this is achieved by differentially modulating two different types of reciprocally connected inhibitory neurons promoting opposing actions. The modulation of these inhibitory neurons influences the activity in the output layer of the network towards encoding more frequently an active type of response and less frequently a protective type of response in larvae fed on sugar compared to those fed on a balanced diet. The information about the internal state is conveyed to the inhibitory neurons through homologues of the vertebrate neuropeptide Y known to be involved in regulating feeding behavior.

Publisher

Cold Spring Harbor Laboratory

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3