WDR88, CCDC11, and ARPP21 genes indulge profoundly in the desmoplastic retort to prostate and breast cancer metastasis

Abstract

Abstract.Microarray technology has unlocked doors to a multitude of open analysis problems that if conceived with efficacy may uncover varied genotypic and phenotypic traits. Algorithms belonging to different cultures in computer science have been applied to gene expression data to derive correlation and stratification parameters. While most outcomes are subject to clinical validation, majority of which get declined, the search for the precisely targeted therapeutic agents is still on. This paper is an effort in the similar direction and strives to delineate genes with significant stromal signatures. We suggest a corroborative indulgence of a human laterality disorder gene, CCDC11 in the metastasis, in addition to the role of WDR88 and ARPP21 genes has been further materialized in the analysis. Another standout aspect of the study has been the associated implications of the genes in rare disorders of male breast and female prostate cancers. There is also a threshold proposal that stratifies “safe” expression space for genes. Complimentarily, the manuscript serves as an expedient protocol for anyone seeking microarray data analysis, particularly in R.