Ubigen: Interactive Ranking and Enrichment Test for Ubiquitously Expressed Genes

Abstract

SummaryWe provide an interactive web service to score and rank human genes by their abundance and invariance of expression across all samples in the GTEx database. Users may provide a list of genes to have these scored and ranked accordingly. A one-sided Wilcoxon rank sum test determines a p-value to indicate if the genes from the list score higher than expected by chance. It is possible to interactively control the parameters and instantly observe the effects on the ranking for each of the submitted genes of interest. A genome-wide sliding-window analysis finds that the genes with both the highest and the lowest ranks feature more GO term annotations, indicating that the scoring carries biological relevance.Availability and Implementationhttps://ubigen.uni-rostock.deContactelias.projahn@uni-rostock.de