Abstract
Human brain cellular assemblies generate emergent oscillations up to very high frequencies that can exceed the known firing rates of individual neurons. Using advanced intracranial microEEG recordings in a cohort of patients with epilepsy, we identified short-lasting local field oscillations with frequencies between 2 and 8 kHz. These ultra fast oscillations were consistently and locally detected in epileptic hippocampi but were extremely rare in normal brain tissue. The observed ultra high frequency oscillations may reflect local circuit hyperexcitability and we use a simple model to demonstrate the feasibility that these local fields are emergent oscillations representing the crest of collective high frequency neuronal unit activity.
Publisher
Cold Spring Harbor Laboratory
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