Author:
Chorlian David B.,Meyers Jacquelyn L.,Manz Niklas,Zhang Jian,Kamarajan Chella,Pandey Ashwini,Wang Jen-Chyong,Plawecki Martin,Edenberg Howard,Goate Alison,Tischfield Jay,Porjesz Bernice
Abstract
AbstractTo characterize systemic changes in genetic effects on brain development, the age variation of the associations of cholinergic genetic variants and theta band event-related oscillations (EROs) was studied in a sample of 2140 adolescents and young adults, ages 12 to 25 from the COGA prospective study. The theta band EROs were elicited in visual and auditory oddball (target detection) tasks and measured by EEG recording. Associations were found to vary with age, sex, task modality (auditory or visual), and scalp locality. Seven of the twenty-one muscarinic and nicotinic cholinergic SNPs studied in the analysis, fromCHRM2, CHRNA3, CHRNA5, andCHRNB4, had significant effects on theta band EROs with considerable age spans for some sex-modality combination. No SNP-age-modality combination had significant effects in the same direction for males and females. Results suggest that nicotinic receptor associations are stronger before age 18, while muscarinic receptor associations are stronger after age 18.
Publisher
Cold Spring Harbor Laboratory