Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

Author:

Cousminer Diana L.1,Berry Diane J.2,Timpson Nicholas J.3,Ang Wei4,Thiering Elisabeth5,Byrne Enda M.6,Taal H. Rob789,Huikari Ville10,Bradfield Jonathan P.11,Kerkhof Marjan8,Groen-Blokhuis Maria M.12,Kreiner-Møller Eskil13,Marinelli Marcella141516,Holst Claus17,Leinonen Jaakko T.1,Perry John R.B.181920,Surakka Ida121,Pietiläinen Olli122,Kettunen Johannes121,Anttila Verneri1222324,Kaakinen Marika1025,Sovio Ulla2627,Pouta Anneli25,Das Shikta26,Lagou Vasiliki1928,Power Chris2,Prokopenko Inga1928,Evans David M.3,Kemp John P.329,St Pourcain Beate29,Ring Susan29,Palotie Aarno12223,Kajantie Eero2130,Osmond Clive31,Lehtimäki Terho32,Viikari Jorma S.33,Kähönen Mika34,Warrington Nicole M.4,Lye Stephen J.35,Palmer Lyle J.3536,Tiesler Carla M.T.537,Flexeder Claudia5,Montgomery Grant W.6,Medland Sarah E.6,Hofman Albert78,Hakonarson Hakon113839,Guxens Mònica141516,Bartels Meike12,Salomaa Veikko21,Murabito Joanne M.40,Kaprio Jaakko14142,Sørensen Thorkild I.A.1743,Ballester Ferran164445,Bisgaard Hans13,Boomsma Dorret I.12,Koppelman Gerard H.46,Grant Struan F.A.113839,Jaddoe Vincent W.V.789,Martin Nicholas G.6,Heinrich Joachim5,Pennell Craig E.4,Raitakari Olli T.34,Eriksson Johan G.47214849,Smith George Davey3,Hyppönen Elina2,Järvelin Marjo-Riitta1025505152,McCarthy Mark I.192853,Ripatti Samuli12122,Widén Elisabeth1, ,

Affiliation:

1. Institute for Molecular Medicine, Finland (FIMM),

2. Centre for Paediatric Epidemiology and Biostatistics, MRC Centre for Epidemiology of Child Health, UCL Institute of Child Health, London, UK,

3. The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine,

4. School of Women's and Infants' Health, The University of Western Australia, Perth, WA, Australia,

5. Institute of Epidemiology I, Helmholtz Zentrum München— German Research Center for Environmental Health, Neuherberg, Germany,

6. Queensland Institute of Medical Research, Brisbane, Australia,

7. The Generation R Study Group,

8. Department of Epidemiology,

9. Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands,

10. Institute of Health Sciences,

11. Center for Applied Genomics,

12. Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, The Netherlands,

13. Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Denmark,

14. Center for Research in Environmental Epidemiology (CREAL), Barcelona, Catalonia, Spain,

15. Hospital del Mar Research Institute (IMIM), Barcelona, Catalonia, Spain,

16. CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Catalonia, Spain,

17. Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark,

18. Genetics of Complex Traits, Exeter medical school, University of Exeter, Exeter, UK,

19. Wellcome Trust Centre for Human Genetics,

20. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK,

21. Department of Chronic Disease Prevention,

22. The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK,

23. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA,

24. Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

25. Biocenter Oulu, University of Oulu, Oulu, PO Box 5000, FI-90014, Finland,

26. Department of Epidemiology and Biostatistics, School of Public Health,

27. Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK,

28. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK,

29. School of Social and Community Medicine, University of Bristol, Bristol, UK

30. Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland,

31. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK,

32. Department of Clinical Chemistry, Fimlab Laboratories, University Hospital and University of Tampere, Finland,

33. Department of Medicine,

34. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland,

35. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada,

36. Ontario Institute for Cancer Research, Toronto, Ontario, Canada,

37. Division of Metabolic Diseases and Nutritional Medicine, Ludwig-Maximilians-University of Munich, Dr von Hauner Children's Hospital, Munich, Germany,

38. Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA,

39. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA,

40. Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA,

41. Department of Public Health,

42. Department of Mental Health & Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland,

43. The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark,

44. Division of Environment and Health, Center for Public Health Research (CSISP), Valencia, Spain,

45. School of Nursing, University of Valencia, Valencia, Spain,

46. Department of Pediatric Pulmonology and Pediatric Allergology, GRIAC Research Institute, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands,

47. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland,

48. Unit of General Practice,

49. Folkhalsan Research Centre, Helsinki, Finland,

50. Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, UK,

51. Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, PO Box 20, FI-90220 Oulu, 90029 OYS, Finland,

52. Department of Children and Young People and Families, National Institute for Health and Welfare, Aapistie 1, Box 310, FI-90101 Oulu, Finland

53. Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LJ, UK,

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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