Serological Screening of Immunoglobulin G against SARS-CoV-2 Nucleocapsid and Spike Protein before and after Two Vaccine Doses among Healthcare Workers in Japan

Author:

Hiramoto Suguru1,Miyashita Daichi1,Kimura Takao1,Niwa Takahiko1,Uchida Azusa1,Sano Maika2,Murata Mai1,Nagasawa Takumi1,Tsunekawa Katsuhiko1,Aoki Tomoyuki2,Yoshida Akihiro2,Kato Toshimitsu3,Yanagisawa Kunio3,Tokue Yutaka3,Murakami Masami1

Affiliation:

1. Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine

2. Clinical Laboratory Center, Gunma University Hospital

3. Infection Control and Prevention Center, Gunma University Hospital

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference19 articles.

1. Bar-On, Y.M., Goldberg, Y., Mandel, M., Bodenheimer, O., Freedman, L., Alroy-Preis, S., Ash, N., Huppert, A. & Milo, R.(2021) Protection against Covid-19 by BNT162b2 booster across age groups. N. Engl. J. Med., 385, 2421-2430.

2. Bergwerk, M., Gonen, T., Lustig, Y., Amit, S., Lipsitch, M., Cohen, C., Mandelboim, M., Levin, E.G., Rubin, C., Indenbaum, V., Tal, I., Zavitan, M., Zuckerman, N., Bar-Chaim, A., Kreiss, Y., et al.(2021) Covid-19 breakthrough infections in vaccinated health care workers. N. Engl. J. Med., 385, 1474-1484.

3. Brown, C.M., Vostok, J., Johnson, H., Burns, M., Gharpure, R., Sami, S., Sabo, R.T., Hall, N., Foreman, A., Schubert, P.L., Gallagher, G.R., Fink, T., Madoff, L.C., Gabriel, S.B., MacInnis, B., et al.(2021) Outbreak of SARS-CoV-2 infections, including COVID-19 vaccine breakthrough infections, associated with large public gatherings - Barnstable County, Massachusetts, July 2021. MMWR Morb. Mortal. Wkly. Rep., 70, 1059-1062.

4. Espenhain, L., Funk, T., Overvad, M., Edslev, S.M., Fonager, J., Ingham, A.C., Rasmussen, M., Madsen, S.L., Espersen, C.H., Sieber, R.N., Stegger, M., Gunalan, V., Wilkowski, B., Larsen, N.B., Legarth, R., et al. (2021) Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021. Euro Surveill., 26, 2101146.

5. Favresse, J., Bayart, J.L., Mullier, F., Dogne, J.M., Closset, M. & Douxfils, J.(2021) Early antibody response in health-care professionals after two doses of SARS-CoV-2 mRNA vaccine (BNT162b2). Clin. Microbiol. Infect., 27, 1351 e5-1351 e7.

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