Affiliation:
1. Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt
Abstract
The synthesis is described of a series of new non-nucleoside analogues of the reverse transcriptase inhibitor TNK-651 from quinazoline-2,4(1 H,3 H)-diones. Compounds 2a–c were silylated and treated with benzyl chloromethyl ether in the presence of CsI to give 1-benzyloxymethylquinazoline derivatives 3a–c. Treatment of the silylated quinazolinediones 2a–c with the appropriate acetals 5a–e in the presence of TMS triflate afforded the corresponding TNK-651 analogues 6–10.
Cited by
10 articles.
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