Synthesis of 3-benzylxanthine and Lumazine Analogues-Reference-Cited by-同舟云学术

Synthesis of 3-benzylxanthine and Lumazine Analogues

Published:2005-04 Issue:4 Volume:2005 Page:262-266
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Ashry El Sayed H. El¹,Youssif Shaker²,Ahwany Maged El²,Sanan Mohamed El²

Affiliation:

1. Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt

2. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt

Abstract

Several xanthines (7–13) are prepared by the cyclisation of 1-benzyl-5,6-diaminouracil with single-carbon inserting agents such as aromatic aldehydes, formamides, acetic anhydride, carbon disulfide, and nitrous acid. Treatment of 6-amino-1-benzyl-5-nitrosouracil with anilinobenzylidene derivatives (14–18) affords 7-hydroxyxanthines (19–23). Cyclisation of the diaminouracil 3 with glyoxal, benzil, and diethyl oxalate leads to lumazines (25–28).

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/0308234054213438

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