Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines

Author:

Naikoo Rayees Ahmad1,Kumar Rupesh1ORCID,Sharma Rashmi1,Mahajan Dinesh2ORCID,Bhargava Gaurav1ORCID

Affiliation:

1. Department of Chemical Sciences, I. K. Gujral Punjab Technical University, Kapurthala, Punjab 144603, India

2. Translational Health Science and Technology Institute, Faridabad, Haryana, India

Abstract

This work describes the highly regio-selective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-aminopyrimidinones with good to excellent yields under ambient conditions.

Funder

I. K. Gujral Punjab Technical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference37 articles.

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3. S.Milstien , G.Kapatos , R. A.Levine and B.Shane , Chemistry and Biology of Pteridines and Folates: Proceedings of the 12th International Symposium on Pteridines and Folates, National Institutes of Health , Springer Science & Business Media , Bethesda, Maryland , 2012

4. An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl2-Catalyzed Three-Component Coupling Reaction

5. Effects of high-lignin-loading on thermal, mechanical, and morphological properties of bioplastic composites

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