Synthesis of Pyrrolo[2,3-b]pyrazines Through Sonogashira Coupling Reaction of 5,6-dichloropyrazine-2,3-dicarbonitrile with Hydrazine, Phenylacetylene and Various Aldehydes-Reference-Cited by-同舟云学术

Synthesis of Pyrrolo[2,3-b]pyrazines Through Sonogashira Coupling Reaction of 5,6-dichloropyrazine-2,3-dicarbonitrile with Hydrazine, Phenylacetylene and Various Aldehydes

Published:2014-12 Issue:12 Volume:38 Page:762-764
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Bakherad Mohammad¹,Keivanloo Ali¹,Omidian Mina¹,Samangooei Shahrzad¹

Affiliation:

1. School of Chemistry, Shahrood University of Technology, Shahrood, Iran

Abstract

The Pd–Cu catalysed one-pot multicomponent reaction of 5,6-dichloropyrazine-2,3-dicarbonitrile with hydrazine, phenylacetylene, and a variety of aldehydes provides an efficient and direct method for the preparation of 5-(arylideneamino)-6-phenyl-5H-pyrrolo[2,3- b]pyrazine-2,3-dicarbonitriles.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751914X14180425794376

Reference17 articles.

1. Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties

2. Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase

3. Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors

4. Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR Study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects

5. Mechanism of CDK5/p25 Binding by CDK Inhibitors

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